Since 2019 the Association for Community Empowerment Solutions (ACESWorld) has worked with more than 1100 adolescent girls in rural Colombia, Ghana, Kenya, and Uganda to understand better the barriers to their education, health, and well-being. Although reliable access to sanitary pads and reproductive health education is often insufficient to improve health and education outcomes, our analysis suggests that access to sanitary pads and reproductive health education within more comprehensive programming can positively affect girls’ education and health outcomes. Based on our analyses, ACESWorld developed the Activities, Skills, and Knowledge for Girls program, a unified approach to reproductive health, life skills, and human rights education to empower adolescent girls to lead whole and healthy lives via evidence-based educational programming. We understand that education is crucial if girls develop the adaptive skills necessary to transform social and economic structures, improve health and education outcomes and act as change agents.